Best Overall Tank Cleaner · 1 of 6
Unique Clean-It Liquid RV Black & Holding Tank Cleaner

- 32 oz enzyme and probiotic liquid
- Works in 48 to 72 hours
- Septic safe, all tank types
Our take
Best for a periodic deep clean when routine treatments do not keep up.
Why it made the shortlist
Unique Clean-It is a 32 oz liquid enzyme and probiotic black and holding tank cleaner that breaks down solid waste, toilet paper and residue left on tank walls. It lists a 48 to 72 hour working time with no driving required and is septic safe and compatible with all RV and marine holding tanks.
Against Restore-It, it is a general deep clean instead of a sensor treatment. Against Store-It, it handles existing buildup rather than storage.
What works
- Breaks down waste and toilet paper
- No driving needed for the 48 to 72 hour soak
- Safe for seals and valves per the listing
- Septic safe and marine compatible
Watch out for
- Best for tanks that still drain
- Not meant for severe blockages






